Gene combination identified as risk factor in success of dental implants

From Dentistry IQ June 29, 2011

Journal of Oral Implantology — The health of the surrounding tissue affects the success of a dental implant. Identifying and reducing risk factors is therefore a key step in the implant process. Now a combination of genes has been identified as a possible indicator of greater tissue destruction, leading to negative outcomes for implants.

The authors of an article in the current issue of the Journal of Oral Implantology report on a study of individuals with the combination of interleukin (IL)-1 allele 2 at IL-1A^-889 and IL-1B⁺³⁹⁵⁴. These people are “genotype positive” and are susceptible to increased periodontal tissue destruction.

Peri-implantitis, or the process of tissue inflammation and destruction around failing implants, is very similar to periodontal disease. The researchers sought to find any association of these genotypes with the severity of peri-implantitis progression and the effect of this combination on treatment outcomes.

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