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Tooth Decay May Result From Immune Response, Not Just Bacterial Plaque

June 3, 2019
by Sherry Eskander, The Varsity


Cavities in teeth may result from an immune system response, not just bacteria, according to a recent U of T study. This counters decades of established thinking in dental research.

In 1970, Dr. John Gabrovsek of the Cleveland Clinic published research in the Journal of Dental Research that found that our immune system may contribute to dental cavities. But during the almost 50 years since it was published, most dental researchers have not taken Gabrovsek’s theory seriously — until U of T’s findings were published in April.

The research was spearheaded by Dr. Yoav Finer and Dr. Michael Glogauer, both professors at the U of T Faculty of Dentistry.

“Glogauer approached me a few years ago, [and] told me that these immune system cells have the same enzymes and more enzymes than bacteria have, so why not check them?” Finer explained to The Varsity.

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