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Researchers Propose New Strategy for Prevention and Treatment of Dental Caries

June 21, 2022
by Chinese Academy of Sciences


One of the most common biofilm-related infections is dental caries which affects more than 60% of children and almost all adults around the world.

The pathogenic bacteria, Streptococcus mutans (S. mutans), induce cavities based on the formation of extracellular polysaccharides (EPS) and their survival in acidic environments. The plaque biofilm formed has the characteristics of water insolubility, retention, and low membrane permeability.

A research group led by Prof. Chen Zhuo from the Fujian Institute of Research on the Structure of Matter of the Chinese Academy of Sciences has developed a pH-responsive metal peroxide nanocomposite for chemodynamic therapy (CDT) by loading Rose Bengal (RB), an antibacterial agent, on copper-doped zinc peroxide nanoparticles (ZnO2-Cu NPs).

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