MTA: The New Material of Choice for Pulp Capping

by Leendert (Len) Boksman, DDS, BSc., FADI, FICD and Manfred (Manny) Friedman BDS, BChD

The use of MTA (Angelus, Brazil/ Clinical Research Dental, London, ON) (Fig. 1) has revolutionized endodontics, since its introduction to dentistry in 19931 (it has been on the dental market since about 1998). In the years since, it has proven to be an exceptional material with a wide range of clinical uses, all scientifically and clinically proven.2-4

Initially recommended as a material for filling root end surgical preparations and for perforation repair, this material is also advocated for immediate apical sealing in teeth with open apices,5 pulpotomies, apexification or apexogenesis in vital teeth with open apices,6-9 and other endodontic and reparative procedures. The extraordinary success in perforation repair since its introduction has motivated its use in these many other areas. This article will look at the success, practicality, and scientific basis for use in pulp capping procedures, particularly in permanent teeth, as MTA has been described very recently as “the material of choice”10 for this treatment.

Properties of MTA
MTA stands for mineral trioxide aggregate, denoting the three dominant oxides in the material’s composition, namely – calcium, aluminum and selenium. Its particle sizes are strictly controlled during manufacturing, as they all need to be less than 10 microns, so that the material may be completely hydrated. MTA has a similar mechanism of action to Calcium Hydroxide11 in that the main component of the material, calcium oxide, when in contact with a humid environment, is converted into calcium hydroxide.12 This results in a high Ph of 12.5, making its surroundings inhospitable for bacterial growth, and producing an anti-bacterial effect for a long period of time. But unlike calcium hydroxide products, such as DYCAL® (Dentsply, York, PA), MTA Angelus (Angelus, Londrina, Brazil/Clinical Research Dental, London, ON) has very low solubility, so it maintains a hard, excellent marginal seal. Finally, unlike most dental materials, MTA actually NEEDS moisture to set so it thrives in a moist environment. Of the commercially available MTA products, MTA Angelus is well suited for pulp capping procedures due to its setting time of 10 minutes, compared with the four hour setting time of the other commercially available MTA. It is also packaged in air-tight bottles, allowing the practitioner to use only what is exactly needed, without introducing undue moisture into the remainder.

Use of MTA for
Direct Pulp Capping
This combination of desirable qualities makes MTA “the material of choice” for cases of pulp exposure in both primary teeth and permanent teeth13,14 (Figs. 2-4). Pulpal exposure is inevitable when excavating many large carious lesions. While many dentists are hesitant to perform direct pulp capping procedures due to previously unpredictable results with conventional materials, MTA is a more predictable and reliable material for direct pulp capping teeth, with reversible pulpitis, as borne out by numerous clinical and histological studies.15-19 Mente et al recently concluded “MTA appears to be more effective than calcium hydroxide for maintaining long-term pulp vitality after direct pulp capping.”20 Numerous other studies show much promise in the long term health of pulps that have been capped using MTA, and years of clinical use have demonstrated the superlative ability of this material in dentin bridge formation (Figs. 5-7).21,22

MTA Clinical Case Presentation
A young female patient presented to the dental office with a large carious exposure on the distal of tooth number 46, as evidenced by the radiograph in Figure 8. Since there was no evidence of periapical rarefaction and no spontaneous pain, it was decided to place a direct pulp cap, if after excavating the caries, the bleeding could be controlled without the use of hemostatic agents. After delivering a mandibular block, and isolation with the rubber dam (Paro Dam – Clinical Research Dental) the clinical photograph of the distal caries is shown in Figure 9. The initial outline form was created using a pear-shaped 332 carbide bur followed by removal of the soft caries with a round carbide bur (Fig. 10). When excavating deep caries and using a regular length bur (Fig. 11) the head of the hand-piece interferes with adequate vision of the caries removal process. As evidenced by Figure 12, the use of a long shank bur (Fig. 13) may complicate access for distal molars, but the distancing of the head of the hand-piece from the occlusal cavo-surface margins allows better visualization of the caries removal process. The final removal of the caries is accomplished with the use of a new sterile diamond round bur, which causes less tissue damage to the pulp than the round carbide bur (which also will be contaminated by the caries excavation). The initial carious pulp exposure is shown in Figure 14. A cotton pledget soaked in 5½% NaOCl is placed over the pulp tissue and removed when the bleeding has stopped (Fig. 15). The area is delicately dried with the use of tissue in cotton pliers (Fig. 16). At this point in the procedure the area is not washed, nor air dried. With the area de-contaminated with the bleach and the bleeding stopped (Fig. 17), the MTA (Angelus, Brazil/Clinical Research Dental) is prepared by mixing the powder and liquid according to the manufacturer’s instructions. The MTA is picked up by a plastic instrument, carried to the exposure site, and is deposited by vibrating the plastic instrument with an ultra-sonic tip (Fig. 18). Figure 19 shows the first increment placed. Similarly a second increment is carried to the exposure site, and is deposited by the vibration of the ultra-sonic (Fig. 20). The vibration simplifies the placement of the MTA with the material smoothly flowing from the plastic instrument and adapting well to the tooth structure facilitating a good seal. To protect the MTA during its setting, a light cured glass ionomer (Fuji 2 LC GC America, Alsip, IL) is injected precisely over the MTA site with a Skini Syringe and Endo-Eze canula (Ultradent/Clinical Research Dental) (Figs. 21, 22) and fully light cured with a Valo broad spectrum curing light (Fig. 23). After careful cutback of the glass ionomer cement and a cleaning of all the margins, a Triodent contoured matrix band was placed, followed by the insertion of a Wave-Wedge. The Wave-Wedge does not cause separation but only serves to adapt the matrix gingivally. A Triodent V3 green molar ring (Triodent/Clinical Research Dental) was placed to create tooth separation and the band was burnished with a ball burnisher to confirm contact with tooth 47 (Fig. 24). Ultra-Etch was placed for 15 seconds over the glass-ionomer, remaining dentin, and enamel margins (Figs. 25, 26), gently washed and lightly dried. A single coat of the Fifth Generation bonding agent MPa (Clinical Research Dental) was applied with a micro-brush (Fig. 27), air thinned and the ethanol solvent evaporated. After light curing with the Valo, the A2 Cosmedent Nano composite (Cosmedent/Clinical Research Dental) was incrementally placed, first laterally to decrease the C factor vectors, light cured, and then the centre valley filled in, adapted and light cured (Fig. 28). After initial recapitulation of the occlusal anatomy with a 7802 bur (Fig. 29), the rubber dam was removed, and a diamond impregnated Groovy Occlusal polishing point (Fig. 30) was used to create the final polish of the nano-filled composite. The final restoration is shown in Figure 31 with the final post-operative radiograph (Fig. 32) showing the close adaptation of the MTA, glass-ionomer and the Cosmedent Nano.

Summary Statement
The clinical and research evidence clearly support the use of MTA as the “new” pulp capping material of choice.OH

Dr. Leendert (Len) Boksman practices part-time at Sunningdale Dental Centre in London, Ontario and is a paid part-time consultant to Clinical Research Dental with the title of Director of Clinical Affairs. He is an adjunct clini
cal professor at the Schulich School of Medicine and Dentistry at the University of Western Ontario. He can be reached at
lboksman@clinicalresearchdental.com

Dr. Manfred (Manny) Friedman maintains a private practice limited to endodontics in London, Ontario and is an adjunct clinical professor in the Division of Restorative Dentistry at the Schulich School of Medicine and Dentistry at the University of Western Ontario. He can be reached at ndofriedman@rogers.com

Oral Health welcomes this original article.

REFERENCES
1. Lee SJ, Monsef M, Torabinejad M. Sealing ability of a mineral trioxide aggregate for repair of lateral root perforations J Endod 1993 Nov;19(11):541-4.
2. Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review-part I: chemical, physical, and antibacterial properties. J Endod 2010;36:16-27.
3. Torabinejad M, Parirokh M. Mineral trioxide aggregate: a comprehensive literature review-part II: leakage and biocompatibility investigations. J Endod 2010;36:190-202.
4. Masoud Parirokh, DMD, MS,* and Mahmoud Torabinejad, DMD, MSD, PhD. Mineral Trioxide Aggregate: A Comprehensive Literature Review-Part III: Clinical Applications, Drawbacks, and Mechanism of Action. JOE – Volume 36, Number 3, March 2010
5. Kratchman SI. Perforation repair and one-step apexification procedures. Dent Clin North Am 2004;48:291-307.
6. Shayegan A, Petein M, Abbeele AV. Beta-tricalcium phosphate, white mineral trioxide aggregate, white Portland cement, ferric sulfate, and formocresol used as pulpotomy agents in primary pig teeth. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:536-42.
7. Holland R, de Souza V, Murata SS, et al. Healing process of dog dental pulp after pulpotomy and pulp covering with mineral trioxide aggregate or Portland cement. Braz Dent J 2001;12:109-13.
8. Ng FK, Messer LB. Mineral trioxide aggregate as a pulpotomy medicament: an evidence-based assessment. Eur Arch Paediatr Dent 2008;9:58-73.
9. Chacko V, Kurikose S. Human pulpal response to mineral trioxide aggregate (MTA): A histological study. J Clin Pediatr Dent 2006;30(3):203-10.
10. Masoud Parirokh, DMD, MS,* and Mahmoud Torabinejad, DMD, MSD, PhD. Mineral Trioxide Aggregate: A Comprehensive Literature Review-Part III: Clinical Applications, Drawbacks, and Mechanism of Action. JOE – Volume 36, Number 3, March 2010, p.400-413
11. Arnaldo Castellucci, MD, DDS. The Use of Mineral Trioxide Aggregate in Clinical and Surgical Endodontics. Dentistry Today March 2003
12. Duarte MA, Demarchi AC, Yamashita JC, Kuga MC, Fraga Sde C. pH and calcium ion release of 2 root-end filling materials. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Mar;95(3):345-7.
13. J. Appl. Oral Sci. vol.13 no.2 Bauru Apr/June 2005. Clinical assessment of mineral trioxide aggregate (MTA) as direct pulp capping in young permanent teeth. J Clin Pediatr Dent. 2006 Winter;31(2):72-6.
14. Tuna D, Olmez A. Clinical long-term evaluation of MTA as a direct pulp capping material in primary teeth. Int Endod J. 2008 Apr;41(4):273-8. Epub 2007 Nov 27.
15. Pitt Ford TR, Torabinejad M, Abedi HR, Bakland LK, Kariyawasam SP. Using mineral trioxide aggregate as a pulp-capping material. J Am Dent Assoc 1996; 127:1491-4.
16. Faraco Jr IM, Holland R (2001) Response of pulp of dogs to capping with mineral trioxide aggregate or a calciumhydroxide cement. Dental Traumatology 17, 163-6.
17. Bogen, G., Kim, J.S. e Bakland, L.K.(2008). Direct pulp capping with mineral trioxide aggregate, JADA, vol.139, pp. 305-315.
18. Bodem O, Blumenshine S, Zeh D, Koch MJ. Direct pulp capping with mineral trioxide aggregate in a primary molar: a case report. Int J Paediatr Dent 2004; 14:376-9.
19. Alexandra Mussolino de Queiroz; Sada Assed; Mario Roberto LeonardoI; Paulo Nelson-Filho; Léa Assed Bezerra da Silva. MTA and calcium hydroxide for pulp capping. J. Appl. Oral Sci. vol.13 no.2 Bauru Apr/June 2005.
20. Johannes Mente, DMD,* Beate Geletneky, DMD,* Marc Ohle,* Martin Jean Koch, MD, DMD, PhD,Ü Paul Georg Friedrich Ding, DMD,Ü DianaWolff, DMD,Ü Jens Dreyhaupt, DSc,á Nicolas Martin, BDS, PhD, FDS,ß Hans Joerg Staehle, MD, DMD, PhD,Ü and Thorsten Pfefferle, DMD* Mineral Trioxide Aggregate or Calcium Hydroxide Direct Pulp Capping: An Analysis of the Clinical Treatment Outcome. JOE – Volume 36, Number 5, May 2010.
21. Min KS, Park HJ, Lee SK, Park SH, Hong CU, Kim HW, Lee HH, Kim EC. Effect of Mineral Trioxide Aggregate on Dentin Bridge Formation and Expression of Dentin Sialoprotein and Heme Oxygenase-1 in Human Dental Pulp. J Endod. 2008 Jun;34(6):666-70.
22. Asgary S, Parirokh M, Eghbal MJ, Ghoddusi J, Eskandarizadeh A. SEM evaluation of neodentinal bridging after direct pulp protection with mineral trioxide aggregate. Aust Endod J. 2006 Apr; 32(1):26-30.

RELATED NEWS

RESOURCES