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Peri-Implantitis: Treatment Options


August 1, 2013
by Mark Nicolucci, BSc, DDS, MS, FRCD(C)

Peri-implantitis has been defined as a localized lesion involving bone loss around an osseointegrated implant.1 Its prevalence has been widely reported4 depending on the chosen threshold and specific study, varying from as low as two percent2 to as high as 58 percent3 of implants. Although a well-accepted threshold and prevalence is currently unavailable, it would appear that peri-implantitis occurs in about one out of every 10 implants.2-4 Despite this high frequency, treatment options for peri-implantitis are poorly studied. A 2011 Cochrane review concluded that the evidence available on peri-implantitis treatment is of insufficient quality and quantity and that more research is needed.28

Peri-implantitis is not only frequent, but a serious complication. Implants have the potential to last a patient’s entire life and peri-implantitis can lead to disintegration and early loss of implants and their supported prostheses. To treat such lesions, one may approach it similarly to periodontitis as both diseases share many features. Both diseases can be initiated with periodontal pathogens and both have similar clinical presentations, including deep probing depths and bleeding. Even the microbiology cultivated from both are similar.5,27 But histologically and pathologically the diseases vary. The microbiology of peri-implantitis is more diverse than that of periodontitis, with lower levels of red complex species.26 Histologically, peri-implantitis is much more infiltrative near the alveolar crest and often lacks a protective layer of tissue over the bone as we typically see in periodontitis.5,6 But most importantly to clinicians, the diseases do not respond to treatment similarly.

Peri-implantitis lesions do not respond well to improved oral hygiene and professional cleanings as is highly effective with periodontitis.7,19 This is not to understate the importance of oral hygiene and professional maintenance in the prevention of peri-implantitis. But once peri-implantitis develops, conservative therapy appears ineffective. Non-surgical treatment of peri-implantitis using laser or air abrasive systems has shown poor results.8 Studies evaluating chemotherapeutics and mechanical debridement show minimal resolution.7 A recent study attempting the use of photodynamic therapy to treat peri-implantitis lesions was also unsuccessful.9 In summary, non-surgical treatments have not been able to predictably arrest peri-implantitis.7

The only treatment that appears effective at resolving peri-implantitis appears to be surgical therapy. But surgical resective therapy is only partially effective. In 2003, Leonhardt found surgical and antimicrobial treatment effective in just over half of peri-implantitis lesions over a period of five years. Heitz-Mayfield et al. (2008) showed that an antimicrobial protocol with surgical flap access was able to stop the progression of peri-implantitis in 90 percent of cases for the short term (one year), but bleeding on probing persisted in nearly 50 percent of those cases.10 Similar results were found by other authors.11 Although a resective surgical approach appears to improve results, it is the combination of surgical access and regenerative procedures that we have seen the most success with. Schwarz et al. (2008) found regenerative surgical treatment to be effective over two years, resulting in cessation of peri-implant bone loss and a reduction of bleeding on probing from 80 percent to 34 percent.12 Froum et al. (2012) also demonstrated the effectiveness of surgical regeneration where he arrested peri-implantitis and reduced bleeding on probing over three to seven years13 (Figs. 1A–2C).

Unfortunately, not all peri-implantitis lesions are favourable to regeneration. For implants with thin facial and lingual walls, peri-implantitis typically does not produce a crater-form defect with four walls. In some of these cases, the defect will present as a complete loss of the surrounding bony walls leaving regeneration as an unpredictable treatment choice. Aljateeli et al. (2012) proposed a decision tree based upon the defect morphology.15 If the defect had sufficient walls (two or greater), regeneration was attempted, but if there was zero or one wall, an apically positioned flap (APF) was suggested with implantoplasty (i.e., drilling the implant surface to remove the threads and outer surface).15 The theoretical benefit of implantoplasty is the production of a surface that is less adherent to bacterial colonization and a form of surface decontamination.

Charalampakis et al. (2011) evaluated the longevity and incidence of relapse of multiple different treatments on peri-implantitis lesions.27 Over half of the cases he evaluated relapsed and were not controlled. Smoking and early disease development were associated with higher rates of relapse and surgical therapy with lower rates of relapse.27 This means peri-implantitis is not just hard to treat, but treated cases must be watched closely as relapse is common (Fig. 3).

In all of the treatments proposed, one of the critical steps was always surface decontamination. The complex modern surface topography of implants offers an excellent haven for bacterial growth and the decontamination of such surfaces can be difficult, especially non-surgically. We have several options for surface decontamination. Anti-infective treatments aim to detoxify the implant surface, such as with chlorhexidine, tetracycline, metronidazole, citric acid, laser and photodynamic therapy. Mechanical debridement aims to remove the biofilm wholly, such as with titanium, plastic or steel curettes, saline rinse, cotton gauze, air abrasion, or implantoplasty. Many clinicians will choose a combination of treatments in an attempt to ensure that surface decontamination is successful.

Multiple studies have evaluated the efficacy of the different surface treatments. Schwarz et al. (2011) compared surface decontamination using laser (Er:YAG) versus plastic curettes with saline-soaked cotton pellets and found no difference in outcome.16 Meyle (2012) performed a literature review comparing different surface treatments and found no difference between mechanical debridement, antiseptic use, air abrasion, photodynamic or laser therapy.19 However, one study did find positive results comparing implantoplasty as a surface decontamination versus mechanical debridement. Romeo et al. (2005, 2007) demonstrated that implantoplasty improved surgical non-regenerative treatment of peri-implantitis, reducing probing depths from 5.5 to 3.6mm and the average bleeding index from 2.3 to 0.5.17,18 In Claffey et al.’s 2008 review of surgical treatments of peri-implantitis, he states,”…[implantoplasty] could be of value when treating peri-implantitis and should be considered.”21 Unfortunately, no further comparative research has been conducted on implantoplasty to support these findings.

Recently (2013), Schwarz et al. used a combination of implantoplasty of the coronal non-regenerable portion of peri-implant defects and grafting the regenerable apical portion to show excellent short-term results.24 But the implantoplasty was only used for the anticipated supracrestal portion of the implant, as suggested by Aljateeli et al.’s decision tree15 to reduce bacterial adhesion. There was no evaluation of the impact of implantoplasty as an effective means of surface decontamination (Figs. 4A–4I).

Implantoplasty provides an absolute decontamination of the implant surface, but four concerns exist: heat production, deposit of implant material into the surgical field, damage to the implant surface and weakening of the implant structure. Heat production is easily managed by effective irrigation and appropriate bur selection.20 In a dog study,22 titanium debris from implantoplasty produced a histological inflammatory cell infiltrate in adjacent tissue but the debris was very minor, undetectable via computed tomography. Both Schwarz16 and Romeo18 have suggested these depositions are not associated with any adverse events clinically. I
mplantoplasty removes the micro- and macro-roughened implant surface but this is commonly thought of as desirable, reducing the roughness of the surface to discourage bacterial colonization.25 The final concern of weakening the implant structure is not often discussed because the amount of surface that needs to be removed is very minimal.

Despite these explanations, few articles discuss implantoplasty. As of the writing of this article, a PubMed literature search on the term “implantoplasty” only provides 11 articles, although that is likely to increase in the future. Implantoplasty can be considered a useful adjunct in resective surgery to smooth and decontaminate portions of an implant left exposed by peri-implantitis lesions. It also may be a beneficial form of decontamination for the whole peri-implant lesion, improving surgical results. Further research is needed to validate the evidence shown by Romeo et al.

Implants have become the superior treatment choice in many cases of edentulism. With the increasing number of implants being placed, peri-implantitis has become much more prevalent. The multitude of treatment options, lack of strong scientific evidence and high incidence of relapse make peri-implantitis a priority to understand. Our ability to successfully and predictably treat this disease will provide a significant benefit to a large portion of our implant patients.OH


Dr. Mark Nicolucci graduated from the University of Western Ontario dental school in 2006 and continued his education with a residency at Temple University in Philadelphia. In 2010, he graduated from Temple University’s periodontology program with a certificate in Periodontology and Oral Implantology. He received a Masters in oral biography and became a diplomat of the International Congress of Oral Implantology and a Fellow of the Misch International Implant Institute. Since returning to Canada, Dr. Nicolucci has been active in lecturing and attending seminars both locally and internationally. He currently works in west Toronto.

Oral Health welcomes this original article.

REFERENCES:

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